Principal investigator: Daeyeon Lee
Co-PI: David Issadore
University: University of Pennsylvania
Industry partner: InfiniFluidics, Inc.
Microfluidic technologies offer unmatched precision for manufacturing lipid nanoparticles, which are essential delivery vehicles for RNA-based vaccines and therapeutics. However, despite their promise, microfluidics have not been widely adopted in industrial manufacturing because channels rapidly clog during operation, leading to unstable production, frequent shutdowns, and high costs. The primary goal of this project is to eliminate fouling-induced failure in microfluidic manufacturing systems and enable continuous, high-throughput, reusable platforms for RNA-LNP production. We will achieve this by developing and validating tethered liquid-like surface coatings that prevent unwanted material buildup on channel walls while maintaining product safety. Working closely with a Pennsylvania-based manufacturing partner, we will demonstrate long-term continuous operation, confirm product safety under manufacturing, and validate scalability for industrial use. This project will train graduate students in advanced manufacturing and position Pennsylvania companies at the forefront of next-generation pharmaceutical manufacturing.